Overview
Alomone Labs is pleased to offer the Ca2+ ATPase Antibody Explorer Kit (#AK-300). This Explorer Kit includes Ca2+ ATPase antibodies with their respective peptide control antigen. An ideal tool for screening purposes.
Compounds
| Product Name | Cat # | Size |
|---|---|---|
Anti-PMCA1 Antibody |
ACP-005 | 1 x 50 µl |
PMCA1 Blocking Peptide |
BLP-CP005 | 1 x 40 µg |
Anti-PMCA2 Antibody |
ACP-002 | 1 x 50 µl |
PMCA2 Blocking Peptide |
BLP-CP002 | 1 x 40 µg |
Anti-PMCA3 Antibody |
ACP-003 | 1 x 50 µl |
PMCA3 Blocking Peptide |
BLP-CP003 | 1 x 40 µg |
Anti-PMCA4 Antibody |
ACP-004 | 1 x 50 µl |
PMCA4 Blocking Peptide |
BLP-CP004 | 1 x 40 µg |
Anti-SERCA1 Antibody |
ACP-011 | 1 x 50 µl |
SERCA1 Blocking Peptide |
BLP-CP011 | 1 x 40 µg |
Anti-SERCA2 Antibody |
ACP-012 | 1 x 50 µl |
SERCA2 Blocking Peptide |
BLP-CP012 | 1 x 40 µg |
Anti-SERCA3 Antibody |
ACP-014 | 1 x 50 µl |
SERCA3 Blocking Peptide |
BLP-CP014 | 1 x 40 µg |
Scientific Background
PMCA belongs to a family of P-type primary ion transport ATPases and is expressed in a variety of tissues, including the brain.
In mammals three genes encode three SERCA pumps. Each transcript undergoes tissue-dependent alternative splicing. SERCA1a and 1b are expressed in adult and neonatal skeletal muscle respectively. SERCA2a is also expressed in skeletal muscle, while SERCA2b is ubiquitously expressed. SERCA3 is expressed in a limited number of non-muscle cells. Although all SERCAs are regulated, SERCA2b undergoes extensive regulation at the protein level, such as protein-protein interaction, phosphorylation and glycosylation.
