Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility Up 100 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Our bioassay
Alomone Labs Cannabichromene activates TRPA1 channels expressed in HEK-293 cells.
Dose-response curve for the activation of human TRPA1 expressing HEK-293 cells loaded with Calcium 5 dye for changes in intracellular Ca2+ measurements. Calcium signal was apparent with 5 µM Cannabichromene (#C-315).
Scientific background
Cannabichromene (CBC) is a member of the cannabinoids, compounds derived from a diterpene structure origin of the marijuana plant Cannabis sativa, and particularly abundant in freshly harvested dry-type Cannabis material. These compounds have been used for over a 1000 years as medicinal agents for the relief of pain, as well as for recreational purposes1.
CBC is a major non-psychotropic phytocannabinoid that inhibits endocannabinoid inactivation and activates the transient receptor potential ankyrin-1 (TRPA1) channels and enzymes of the endocannabinoid system. In addition, it also acts as a TRPM8 antagonist.
CBC selectively reduces inflammation-induced hypermotility in vivo independently from cannabinoid receptors or TRPA11,2.
Several studies have demonstrated that CBC exerts antimicrobial, anti-inflammatory, analgesic and antidepressant-like activity in rodents and has the ability to normalize in vivo intestinal motility in an experimental model of intestinal inflammation3.
Cannabichromene potency tested induced TRPA1-mediated Ca2+ elevation showed efficacy of EC50 of 90 nM1.