Cardiac CaV Channel Antibody Explorer Kit

Voltage-gated calcium channels (Ca_V) mediate calcium influx in response to membrane depolarization and regulate intracellular processes such as contraction, secretion, neurotransmission, and gene expression in many different cell types. Their activity is essential in coupling electrical signals at the cell surface to physiological events in the cell.

Cardiac voltage-gated channels (Ca_V1.2) are a subtype of the Ca_V family. These channels are responsible for excitation-contraction coupling and action potential propagation in the sinoatrial and atrioventricular nodes. The cardiac calcium channels are also known as L-type (“long lasting”) channels due to their tendency to open in response to high membrane potentials and to slowly inactivate (~500ms). Other Ca_V channels expressed in the heart include T-type channels Ca_V3.1 and Ca_V3.2^1,2.