Overview
Alomone Labs is pleased to offer the Cardiac CaV Channel Antibody Explorer Kit (#AK-310). The Explorer Kit contains cardiac CaV channel antibodies, ideal for screening purposes.
Compounds
| Product Name | Cat # | Size |
|---|---|---|
Anti-CaV1.2 (CACNA1C) Antibody |
ACC-003 | 1 x 50 µl |
Cav1.2/CACNA1C Blocking Peptide |
BLP-CC003 | 1 x 40 µg |
Guinea pig Anti-CaV1.2 (CACNA1C) Antibody |
ACC-003-GP | 1 x 50 µl |
Cav1.2/CACNA1C Blocking Peptide |
BLP-CC003 | 1 x 40 µg |
Anti-CaV1.2a (CACNA1C) Antibody |
ACC-013 | 1 x 50 µl |
Cav1.2a/CACNA1C Blocking Peptide |
BLP-CC013 | 1 x 0.15 mg |
Anti-Human CaV1.2 (CACNA1C) Antibody |
ACC-022 | 1 x 50 µl |
Human Cav1.2/CACNA1C Blocking Peptide |
BLP-CC022 | 1 x 40 µg |
Anti-CACNA1G (CaV3.1) Antibody |
ACC-021 | 1 x 50 µl |
CACNA1G/Cav3.1 Blocking Peptide |
BLP-CC021 | 1 x 40 µg |
Anti-CaV3.2 (CACNA1H) Antibody |
ACC-025 | 1 x 50 µl |
Cav3.2/CACNA1H Blocking Peptide |
BLP-CC025 | 1 x 40 µg |
Anti-CACNG6 (extracellular) Antibody |
ACC-112 | 1 x 50 µl |
CACNG6 (extracellular) Blocking Peptide |
BLP-CC112 | 1 x 40 µg |
Scientific Background
Voltage-gated calcium channels (CaV) mediate calcium influx in response to membrane depolarization and regulate intracellular processes such as contraction, secretion, neurotransmission, and gene expression in many different cell types. Their activity is essential in coupling electrical signals at the cell surface to physiological events in the cell.
Cardiac voltage-gated channels (CaV1.2) are a subtype of the CaV family. These channels are responsible for excitation-contraction coupling and action potential propagation in the sinoatrial and atrioventricular nodes. The cardiac calcium channels are also known as L-type (“long lasting”) channels due to their tendency to open in response to high membrane potentials and to slowly inactivate (~500ms). Other CaV channels expressed in the heart include T-type channels CaV3.1 and CaV3.21,2.
- Catterall, W.A. et al. (2005) Pharmacol. Rev. 57, 411.
- Treinys, R. et al. (2008) Medicina 44, 491.
