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Overview
CAY10593 (VU0155069) (#C-385) is a highly pure, synthetic, and biologically active compound.
Alternative Name (S)-N-(1-(4-(5-Chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)propan-2-yl)-2-naphthamide.
Structure
For research purposes only, not for human use
Applications
Citations (1)
Citations
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Properties
Technical Specifications
MW 462.98
Purity >95%
Molecular formula C26H27ClN4O2.
CAS No. 1130067-06-9
Source Synthetic
PubChem CID 53393949
Chemical name N-[(2S)-1-[4-(5-chloro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]naphthalene-2-carboxamide.
Biological Activity
Target P2X7 receptors, Phospholipase D1 (PLD1)
Effective concentration 1-10 µM.
Activity CAY10593 (VU0155069) is an antagonist of purinergic P2X7 receptors, shown to inhibit ATP-induced ethidium+ uptake in RPMI 8226 cells with IC50 of 2 µM1. It is also a potent and selective inhibitor of phospholipase D1 (IC50 of 46 and 933 nM for PLD1 and PLD2, respectively)2.
References
- Pupovac, A. et al. (2013) Purinergic Signal. 9, 609.
- Lewis, J.A. et al. (2009) Bioorg. Med. Chem. Lett. 19, 1916.
Solubility and Storage
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
Storage of solutions -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.
Scientific Background
References
Scientific background
CAY10593 (VU0155069) is an antagonist of purinergic P2X7 receptors and an inhibitor of phospholipase D1 (PLD1)1. CAY10593 inhibits ATP-induced ethidium+ uptake in RPMI 8226 cells expressing P2X7 receptors in a concentration-dependent manner with an IC50 value of 2 µM1.
The P2X receptors are a family of ligand-gated ion channels present on various cell types. P2X receptors are activated by extracellular ATP and play an important role in many disease states, including inflammatory, immune, neoplastic, musculoskeletal, and neurological disorders1,2.
References
- Pupovac, A. et al. (2013) Purinergic Signal. 9, 609.
- Lewis, J.A. et al. (2009) Bioorg. Med. Chem. Lett. 19, 1916.
Last Update: 08/01/2025
