Overview
Lyophilized Powder yes
Source Synthetic
MW: 309.36
Purity: >99%
Effective concentration 1-100 µM.
Structure
Chemical name 5,6,7,8,9,10-Hexahydro-2-(4-methoxyphenyl)cyclohepta[b]pyrazolo[3,4-d]pyridin-3(2H)-one.
Molecular formula C18H19N3O2.
CAS No.: 111205-55-1
PubChem CID 163844
Activity CGS 20625 acts as a partial agonist at GABA(A) receptors (EC50 = 11.2-23.7 µM)1. It is a potent and selective non-benzodiazepine ligand at the central benzodiazepine receptor (IC50 = 1.3 nM), with anxiolytic and anticonvulsant effects in vivo2.
References-Activity
- Khom, S. et al. (2006) Mol. Pharmacol. 69, 640.
- Williams, M. et al. (1989) J. Pharmacol. Exp. Ther. 248, 89.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at +4°C.
Solubility Soluble in DMSO and ethanol. Centrifuge before use (10000 x g, 5 min).
Storage of solutions Up to three months at -20°C.
Our bioassay
Alomone Labs CGS 20625 activates GABA(A) receptors expressed in Xenopus oocytes.Representative time course of GABA(A) α1/β2 receptor current, activated by 10 µM and 100 µM CGS 20625 (#C-390), as indicated (bars), at a holding potential of -60 mV.
Scientific background
CGS 20625 is a synthetic compound that acts as a potent and selective partial agonist of GABA(A) receptors.
CGS 20625 is a pyrazolopyridine compound that possesses anxiolytic and anticonvulsant characteristics. It binds to a specific recognition site on GABAA receptors containing α1, α2, α3, and α5 subunits1-3.
GABA(A) receptors are members of the Cys-loop superfamily of ligand-gated ion channels. They mediate GABA actions, a major inhibitory neurotransmitter, throughout the central nervous system where it plays an important role in inhibiting cell excitation. GABA(A) receptors are a major target for antiseizure drugs4.
Target GABA(A) receptors
Lyophilized Powder
For research purposes only, not for human use
Last Update: 07/05/2024
Specifications
Citations
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