Overview
- Usala, M. et al. (2003) Br. J. Pharmacol. 140, 1045.
- Hales, T.G. and Lambert, J.J. (1992) Eur. J. Pharmacol. 210, 239.
Alomone Labs Chlormethiazole hydrochloride activates GABA(A) receptors expressed in Xenopus oocytes.Time course of GABA(A) α1/β2 currents, directly activated by 0.25 mM and 1 mM Chlormethiazole hydrochloride (#C-360), reversibly and in a concentration-dependent manner, while membrane potential was held at -60 mV.
- Usala, M. et al. (2003) Br. J. Pharmacol. 140, 1045.
- Vandevred, L. et al. (2014) Br. J. Pharmacol. 171, 389.
- Wilby, M.J. and Hutchinson, P.J. (2004) CNS Drug Rev. 10, 281.
- Nohria, V. and Giller, E. (2007) Neurotherapeutics 4, 102.
Chlormethiazole hydrochloride, a thiazole derivative, is a sedative, hypnotic and anxiolytic compound that has been used for the treatment of alcohol-withdrawal symptoms, status epilepticus and pre-eclampsia.
Chlormethiazole acts as a positive modulator of GABA(A) and glycine receptors and holds structural similarity to the β-subunit-selective compound loreclezole. In several studies, the compound was also shown to have neuroprotective properties in models of ischaemia1,2,3.
GABA(A) receptors are members of the Cys-loop superfamily of ligand-gated ion channels and mediate GABA action, a major inhibitory neurotransmitter, throughout the central nervous system. GABA(A) receptors are considered to be a major target of antiseizure drugs4.
Chlormethiazole hydrochloride (#C-360) is a highly pure, synthetic, and biologically active compound.
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