Overview
Alternative Name Somnevrin hydrochloride
Structure
Scientific background
Chlormethiazole hydrochloride, a thiazole derivative, is a sedative, hypnotic and anxiolytic compound that has been used for the treatment of alcohol-withdrawal symptoms, status epilepticus and pre-eclampsia.
Chlormethiazole acts as a positive modulator of GABA(A) and glycine receptors and holds structural similarity to the β-subunit-selective compound loreclezole. In several studies, the compound was also shown to have neuroprotective properties in models of ischaemia1,2,3.
GABA(A) receptors are members of the Cys-loop superfamily of ligand-gated ion channels and mediate GABA action, a major inhibitory neurotransmitter, throughout the central nervous system. GABA(A) receptors are considered to be a major target of antiseizure drugs4.
For research purposes only, not for human use
Specifications
Applications
Our Bioassay
Our bioassay
Alomone Labs Chlormethiazole hydrochloride activates GABA(A) receptors expressed in Xenopus oocytes.Time course of GABA(A) α1/β2 currents, directly activated by 0.25 mM and 1 mM Chlormethiazole hydrochloride (#C-360), reversibly and in a concentration-dependent manner, while membrane potential was held at -60 mV.
Last Update: 08/01/2025
