Overview
- Parker, N.G. and Brown, C.S. (2000) Ann. Pharmacother. 34, 761.
- Zhan, X.Q. et al. (2012) J. Neurosci. Res. 90, 324.
Alomone Labs Citalopram inhibits KV2.1 channels expressed in Xenopus oocytes.A. Time course of KV2.1 current amplitude, elicited by 100 ms voltage ramp from holding potential of -100 mV to 100 mV, delivered every 10 seconds. Application of 100 µM Citalopram (#C-195) inhibits the KV2.1 current in a reversible manner (indicated by the horizontal bar).
B. Representative current traces before and during application of 100 µM Citalopram as indicated.
Citalopram is an extremely potent and highly selective bicyclic serotonin-reuptake inhibitor (SSRIs) with IC50 value of 275 nM1. The SSRIs selectively potentiate 5-HT neurotransmission by inhibiting serotonin reuptake. Citalopram competes with serotonin and imipramine for a common binding site1. The high specificity results in minimal effects on other neurotransmitter receptors and uptake. Thus, citalopram shows fewer of the anticholinergic or adrenolytic side effects associated with other psychotropic agents and has minimal cardiotoxic side effects.
Citalopram is structurally unrelated to other antidepressants, but it contains the chemical features associated with reversal of drug resistance2. Citalopram is used for the management of depression. Citalopram is also used for treating obsessive compulsive disorder (OCD), panic disorder, premenstrual dysphoric syndrome (PMDD), anxiety disorder, and posttraumatic stress disorder.
Citalopram also blocks KV2.1 and KV2.2 channels3.
