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Overview
Cl-HIBO (#C-355) is a highly pure, synthetic, and biologically active compound.
Alternative Name 4-Chlorohomoibotenic acid
Structure
For research purposes only, not for human use
Applications
Specifications
Properties
Technical Specifications
MW 206.58
Purity >99% (HPLC)
Molecular formula C6H7ClN2O4.
CAS No. 909400-43-7
Source Synthetic
PubChem CID 4694356
Chemical name 2-amino-3-(4-chloro-3-oxo-1,2-oxazol-5-yl)propanoic acid.
Biological Activity
Target AMPA receptors
Effective concentration 0.1-100 µM.
Activity Cl-HIBO is an AMPA receptor agonist, highly selective for GluR1 and GluR2 subunit-containing receptors (EC50 for rat recombinant homomeric GluR1, 2, 3 and 4 receptors are 4.7, 1.7, 2700 and 1300 μM, respectively)1.
References
- Bjerrum, E.J. et al. (2003) J. Med. Chem. 46, 2246.
Solubility and Storage
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility Up to 20 mM in H2O (slow). Centrifuge all products before reconstitution (10000 x g 5 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C. It is recommended to aliquot reconstituted stock solutions.
Scientific Background
References
Scientific background
Cl-HIBO (chloro-homoibotenic acid) acts as a full agonist at AMPA receptors (AMPARs). Cl-HIBO is the most selective agonist reported to-date for GluR1/2. Thus, the compound is considered to be a valuable tool for studying the biological behavior and distribution of AMPARs1.
The ionotropic glutamate AMPA receptors are the primary receptors that mediate fast excitatory synaptic transmission in the mammalian brain. The majority of this transmission in the mammalian central nervous system is mediated by the release of glutamate from the presynaptic terminal and its binding to glutamate receptors on the postsynaptic membrane2.
References
- Bjerrum, E.J. et al. (2003) J. Med. Chem. 46, 2246.
- Guntupalli, S. et al. (2016) Neural Plast. 2016, 3204519.
Last Update: 08/01/2025
