Overview
Cat #: AK-420_KIT
Size: 18 Vials
Form: Lyophilized
Alomone Labs is pleased to offer the Connexin Antibody Explorer Kit (#AK-420). This Explorer Kit includes connexin antibodies, ideal for screening purposes.
For research purposes only, not for human use
Compounds
| Product Name | Cat # | Size |
|---|---|---|
Anti-Connexin-26 (GJB2) Antibody |
ACC-212 | 1 x 50 µl |
Connexin-26/GJB2 Blocking Peptide |
BLP-CC212 | 1 x 40 µg |
Anti-Connexin-29 (extracellular) Antibody |
ACC-223 | 1 x 50 µl |
Connexin-29 (extracellular) Blocking Peptide |
BLP-CC223 | 1 x 40 µg |
Anti-Connexin-31 (GJB3) Antibody |
ACC-213 | 1 x 50 µl |
Connexin-31/GJB3 Blocking Peptide |
BLP-CC213 | 1 x 40 µg |
Anti-Connexin-32 Antibody |
ACC-211 | 1 x 50 µl |
Connexin-32 Blocking Peptide |
BLP-CC211 | 1 x 40 µg |
Anti-Connexin-36 Antibody |
ACC-209 | 1 x 50 µl |
Connexin-36 Blocking Peptide |
BLP-CC209 | 1 x 40 µg |
Anti-Connexin-37 Antibody |
ACC-204 | 1 x 50 µl |
Connexin-37 Blocking Peptide |
BLP-CC204 | 1 x 40 µg |
Anti-Connexin-40 (GJA5) Antibody |
ACC-205 | 1 x 50 µl |
Connexin-40/GJA5 Blocking Peptide |
BLP-CC205 | 1 x 40 µg |
Anti-Connexin-43 Antibody |
ACC-201 | 1 x 50 µl |
Connexin-43 Blocking Peptide |
BLP-CC201 | 1 x 40 µg |
Anti-Connexin-45 (GJC1) Antibody |
ACC-207 | 1 x 50 µl |
Connexin-45/GJC1 Blocking Peptide |
BLP-CC207 | 1 x 40 µg |
Scientific Background
Scientific Background Connexins (Cx) are integral membrane proteins consisting of four transmembrane domains, two extracellular loops, one intracellular loop and intracellular N- and C-termini. The 21 members belonging to this family form homomeric or heteromeric hexamers generally termed connexons or hemi-channels. In turn, these hemi-channels further assemble in a head-to-head manner, thus forming gap junction channels1,2. Connexins are ubiquitously expressed and their activity is regulated at the expression level and by post-translational modifications1. For example, Connexin-43 (Cx43) protein level is regulated by its turnover rate and by phosphorylation of various residues which ultimately determines its activity rate1.
References
- Goodenough, D.A. and Paul, D.L. (2011) Cold Spring Harb. Persp. Biol. 2009, 1.
- Nakagawa, S. et al. (2010) Curr. Opin. Struct. Biol. 20, 423.
