Overview
Lyophilized Powder yes
Source Synthetic
MW: 186.16
Purity: >98%
Effective concentration 200-500 nM.
Structure
Chemical name 7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid.
Molecular formula C8H10O5.
CAS No.: 145-73-3
Activity Endothall is a cantharidin analogue and potently inhibits PP2A (IC50 = 90 nM) with a slight effect on PP1 (IC50 = 5 µM)1.
References-Activity
- Li, Y.M. et al. (1993) Biochem. Pharmacol. 46, 1435.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility Water. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to two weeks at 4°C or six months at -20°C.
References - Scientific background
- Li, Y.M. et al. (1993) Biochem. Pharmacol. 46, 1435.
- Herzig, S. and Neumann, J. (2000) Physiol. Rev. 80, 173.
Scientific background
Endothall is a synthetic structural analogue of Cantharidin (#C-170), widely used in agriculture as a pesticide and herbicide for both terrestrial and aquatic weeds1,2.
Endothall was found as a potent inhibitor of spinach leaf Protein Phosphatase 1 and Protein Phosphatase 2A but a less potent inhibitor than Cantharidin for mammalian liver Protein Phosphatase 1 and Protein Phosphatase 2A.
Endothall is a more effective herbicide than Cantharidin possibly due to the expression of various Protein Phosphatases in plant or to permeability differences1,2.
Lyophilized Powder
Endothall (#E-180) is a highly pure, synthetic, and biologically active compound.
For research purposes only, not for human use
Last Update: 02/01/2024
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