Overview
Alternative Name Anexate, Flumazepil, Romazicon, Lanexat, Ro 15-1788
Lyophilized Powder yes
Source Synthetic
MW: 303.3
Purity: >95%.
Effective concentration 1 nM - 1 µM.
Structure
Chemical name ethyl 8-fluoro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate.
Molecular formula C15H14FN3O3.
CAS No.: 78755-81-4
PubChem CID 3373
Activity Flumazenil is a GABA(A) receptor antagonist1.
References-Activity
- Atack, J.R. et al. (1999) Neuropsychopharmacology 20, 255.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility 25 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Our bioassay
Alomone Labs Flumazenil inhibits specific binding of Flunitrazepam to rat brain GABA(A) receptors.Percent inhibition of specific binding of 1 nM [3H] Flunitrazepam to membranes from whole rat brain (except cerebellum) was plotted against concentrations of Flumazenil (#F-145), (green circles) and of Diazepam (assay standard, black squares) and used to calculate IC50 and Ki values for Flumazenil (IC50 ≈ 7.35 nM, and Ki ≈ 5.99 nM).
Target GABA(A) receptors
Lyophilized Powder
For research purposes only, not for human use
Last Update: 30/03/2021
Specifications
Citations
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