Overview
Alternative Name Colforsin, Coleonol
Lyophilized Powder yes
Origin Coleus forskohlii.
Source Natural
MW: 410.5
Purity: >97% (HPLC)
Effective concentration 5-10 μM.
Structure
Chemical name [3R-(3a,4ab,5b,6b,6aa,10a,10ab,10ba)]-5-(Acetyloxy)-3-e thenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pent amethyl-1H-naphtho[2,1-b]pyran-1-one.
Molecular formula C22H34O7.
CAS No.: 66575-29-9
Activity Forskolin increases cAMP levels by activating adenylate cyclase1.
References-Activity
- Awad, J.A. et al. (1983) J. Biol. Chem. 258, 2960.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility DMSO, ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to four months at 4°C.
Our bioassay
Alomone Labs Forskolin activates (in vivo) adenylate cyclase in NIH/C6 neuroblastoma cells.Cells were pre-incubated for 30 min with IBMX (10 mM) and then stimulated for 30 min with different concentrations of Forskolin (#F-500). Cellular cAMP levels were measured by an ELISA kit.
Scientific background Forskolin is a cell permeable diterpenoid isolated from Coleus forskohlii. Forskolin has a unique ability to stimulate adenylate cyclase activity and increase cyclic adenosine monophosphate (cAMP)1-10.
Lyophilized Powder
For research purposes only, not for human use
Last Update: 12/09/2024
Specifications
Citations
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