Frescolat MGA

Applications
Specifications
Scientific Background

Overview

Cat #: APC-047

Purity: >97%

CAS No.: 63187-91-7

MW: 228.33

Frescolat MGA (#F-165) is a highly pure, synthetic, and biologically active compound.

Certificate of Analysis SDS

Alternative Name Menthone 1,2-glycerol ketal

Structure

For research purposes only, not for human use

Applications

Specifications

Properties

Technical Specifications

MW 228.33

Purity >97%

Molecular formula C₁₃H₂₄O₃.

Form Colorless Liquid

CAS No. 63187-91-7

Source Synthetic

PubChem CID 162184

Chemical name (9-methyl-6-propan-2-yl-1,4-dioxaspiro[4.5]decan-3-yl)methanol.

Biological Activity

Target TRPM8 channel

Effective concentration 0.1-10 µM.

Activity Frescolat MGA is a TRPM8 channel activator and cooling agent. It activates mouse TRPM8 channels with EC₅₀ of 4.8 µM¹.

References

Behrendt, H.J. et al. (2004) Br. J. Pharmacol. 141, 737.

Solubility and Storage

Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C. Store in a cool and dry place.

Solubility Up to 200 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).

Storage of solutions Up to three months at -20°C.

Scientific Background

Scientific background

Frescolat MGA is a synthetic compound that acts as a TRPM8 channel activator. Studies show that Frescolat MGA has the ability to activate mouse TRPM8 channels and to produce concentration-dependent increase in Ca²⁺ levels with an EC₅₀ value of 4.8 µM¹.

TRPM8 channel is a member of the TRP channels superfamily. TRPM8 is Ca²⁺-permeable, nonselective cation channel that is activated by temperatures in the range of 8–28°C and by chemical agonists such as menthol and icilin. TRPM8 is specifically expressed in temperature-sensing trigeminal and dorsal root ganglion neurons and is up-regulated in prostate cancer and other malignancies^1,2.

References