Overview
Alternative Name Menthone 1,2-glycerol ketal
Source Synthetic
MW: 228.33
Purity: >97%
Form Colorless Liquid
Effective concentration 0.1-10 µM.
Structure
Chemical name (9-methyl-6-propan-2-yl-1,4-dioxaspiro[4.5]decan-3-yl)methanol.
Molecular formula C13H24O3.
CAS No.: 63187-91-7
PubChem CID 162184
Activity Frescolat MGA is a TRPM8 channel activator and cooling agent. It activates mouse TRPM8 channels with EC50 of 4.8 µM1.
References-Activity
- Behrendt, H.J. et al. (2004) Br. J. Pharmacol. 141, 737.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C. Store in a cool and dry place.
Solubility Up to 200 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
Storage of solutions Up to three months at -20°C.
Our bioassay
Alomone Labs Frescolat MGA activates TRPM8 channels expressed in HEK-293 cells.Dose response curve of the activation of TRPM8, shown as relative fluorescence plotted against increasing concentrations of Frescolat MGA (#F-165). EC50 was determined at 1.77 µM. Cells were loaded with Calcium-5 dye. Changes in intracellular Ca2+ following agonist application were detected as changes in 485 nm/525 nm fluorescence (RFU).
Scientific background
Frescolat MGA is a synthetic compound that acts as a TRPM8 channel activator. Studies show that Frescolat MGA has the ability to activate mouse TRPM8 channels and to produce concentration-dependent increase in Ca2+ levels with an EC50 value of 4.8 µM1.
TRPM8 channel is a member of the TRP channels superfamily. TRPM8 is Ca2+-permeable, nonselective cation channel that is activated by temperatures in the range of 8–28°C and by chemical agonists such as menthol and icilin. TRPM8 is specifically expressed in temperature-sensing trigeminal and dorsal root ganglion neurons and is up-regulated in prostate cancer and other malignancies1,2.
Target TRPM8 channel
For research purposes only, not for human use
Last Update: 06/06/2024
Specifications
Citations
Citations
