10-100 µM.

2'MeO6MF is a GABAA receptor modulator, shown to potentiate the response to GABA (EC₁₀) with EC₅₀ ranging from 21 µM to 98 µM, depending on subunit combination, in Xenopus oocytes. Displays anxiolytic-like and sedative effects in mice¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Soluble up to 100 mM in DMSO. Spin down all products before handling.

Store at -20°C for several months. It is recommended to aliquot stock solutions to avoid repeated thawing and freezing.

1-100 µM.

AA 29504 is a positive allosteric modulator of GABA(A) receptors, reducing the EC₅₀ of GABA and gaboxadol at the α₄β₃δ and α₁β₃γ_2S receptors in Xenopus oocytes at over 1 µM. AA 29504, a retigabine analogue, also exhibits some agonistic activity on KCNQ channels (EC₅₀=9.6-13.5 µM)¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at +4°C.

Soluble in DMSO. Centrifuge all product preparations before use (10000 x g, 5 min).

Up to three months at -20°C.

1-100 µM.

CGS 20625 acts as a partial agonist at GABA(A) receptors (EC₅₀ = 11.2-23.7 µM)¹. It is a potent and selective non-benzodiazepine ligand at the central benzodiazepine receptor (IC₅₀ = 1.3 nM), with anxiolytic and anticonvulsant effects in vivo².

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at +4°C.

Soluble in DMSO and ethanol. Centrifuge before use (10000 x g, 5 min).

Up to three months at -20°C.

0.01-1 mM.

Chlormethiazole both directly activates GABA_A receptors (at 0.3 – 1 mM), and potentiates GABA-induced activation at various GABA_A receptor subtypes (with EC₅₀ of 20 – 160 µM)¹. It was also shown to potentiate glycine-induced currents in both bovine chromaffin cells and murine spinal neurons (at 100 µM)².

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored desiccated at -20°C.

Up to 200 mM in H₂O. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C. It is recommended to aliquot reconstituted product for storage.

0.01-10 μM.

Ganaxolone potentiates GABA-evoked chloride currents. In Xenopus oocytes expressing the human GABA(A) receptor subunits α2β1γ2L, α3β1γ2L and α1β1γ2L the respective EC₅₀ values are 94, 122 and 213 nM¹. It is also used as an anticonvulsant, antiepileptic drug².

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

0.1-10 µM.

Isoguvacine hydrochloride is a specific agonist of the GABA(A) receptors, with EC₅₀ of 3.7–17.3 µM, depending on subunit composition¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Up to 100 mM in water. Centrifuge all product preparations before use (10000 x g, 5 min).

Up to four weeks at 4°C or three months at -20°C.

Synthetic peptide

200-400 nM.

MmTx1 is a potent allosteric modulator of GABA(A) receptors¹.

The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Avoid exposure to light.

The product is lyophilized in 0.5 ml conical vial.
Centrifuge the vial before adding solvent (10,000 x g for 5 minutes). The lyophilizate may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed.
Soluble in pure water at high-micromolar concentrations (50 µM - 1 mM). For long-term storage in solution, it is recommended to prepare a stock solution by dissolving the product in double distilled water (ddH₂O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations at 10,000 x g for 5 minutes before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity. Avoid exposure to light.

Store the reconstituted solution at -20°C for the shortest time possible. Avoid multiple freeze-thaw cycles. We do not recommend storing the product in working solutions for longer than a day. Avoid exposure to light.

1-100 µM.

SJM-3 is a novel positive allosteric modulator of GABA(A) receptors at the benzodiazepine modulatory site (pK_i = 6.7), strongly potentiating GABA currents at 30 µM via the binding site for diazepam in the transmembrane domain, while acting as an antagonist at the α+/γ− site¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Soluble in DMSO. Centrifuge before handling (10000 x g, 5 min).

-20°C.

10-100 µM.

Tracazolate is an allosteric modulator of GABA(A) receptors, that was shown to potentiate (EC₅₀ = 1.1-16.7 µM) or inhibit (IC₅₀ = 1.2-4.0 µM) GABA-evoked currents in a subunit combination dependent manner¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored desiccated at -20°C. Protect from light.

Soluble in 1eq. HCl and in DMSO. Centrifuge all product preparations before use (10000 x g, 5 min).

Up to four weeks at 4°C or three months at -20°C.

Synthetic peptide

1- 5 µM.

Waglerin-1 blocks ε subunit of muscle adult nAChR and modulates rodent GABA(A)/GABRA1 receptors^1,2.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.