Overview
- Lu, X. et al. (2005) Neuropeptides 39, 143.
Alomone Labs Galanin (2-11) activates Galanin 2 receptor-mediated Ca2+ mobilization in CHO-K1-Gα16-mt Aequorin cells.Dose response of normalized activation of the Galanin 2 receptor-mediated Ca2+ mobilization, evoked by Galanin (2-11) (#GPG-150). Ca2+ response was detected by measuring aequorin-derived fluorescence following application of Galanin (2-11) at different concentrations. The EC50 measured for Galanin (2-11) is 0.81 nM.
Galanin (2-11) is a neuropeptide that acts as a selective potent galanin 2 and 3 receptor (GalR2/3) agonist. Galanin is a C-terminally amidated 29-residue peptide deriving its name from the N-terminal glycine and C-terminal alanine residue. In humans the peptide contains additional nonamidated serine residue at C terminus. Galanin was firstly isolated from porcine intestine and shown to be widely distributed through the central and peripheral nervous system1-3.
Its biological activity includes contraction or relaxation of gut smooth muscles, inhibition of insulin and somatostatin release, and modulation of hormone secretion from the pituitary and adrenal gland. It is believed that galanin plays an important role as a neuromodulator of endocrine secretion and synaptic transmission1.
Galanin receptors belong to the family of G-protein coupled receptors and consist of three subtypes: GalR1, GalR2, and GalR3. Additional studies show that galanin and its receptors are involved in the transmission and modulation of nociception2.
