Overview
Cat #: AK-545_KIT
Size: 16 Vials
Form: Lyophilized
Alomone Labs is pleased to offer the GPCR Pain-Related Antibody Explorer Kit (#AK-545). The Explorer Kit contains GPCR pain-related antibodies, ideal for screening purposes.
For research purposes only, not for human use
Compounds
Scientific Background
Scientific Background
Cannabinoids have been used in eastern medicine for many years as pain relievers.1 Δ9-tetrahydrocannabinol (THC), the major psychoactive compound in marijuana and hashish, has been shown to interact with two specific cannabinoid receptors: cannabinoid receptor 1 (CB1 Receptor or CB1R) and cannabinoid receptor 2 (CB2 Receptor or CB2R).2
All three classic opioid receptors mediate opioid-induced analgesia. Supraspinal analgesia is mainly mediated by the µ-opioid receptor, whereas µ-, δ-, and κ-receptors participate in the control of pain at the spinal level.3
References
- Brooks, J.W. and Fraquhar-Smith, M.A. (2003) Br. J. Anaesth. 3, 175.
- Howlett, A.C. (2002) Prostaglandins Other Lipid Mediat. 68–69, 619.
- Matthes, H.W. et al. (1998) J. Neurosci. 18, 7285.
