Overview
Lyophilized Powder yes
Source Synthetic
MW: 348.87
Purity: >98%.
Effective concentration 0.1-10 nM.
Structure
Chemical name 1-methyl-N-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)indazole-3-carboxamide;hydrochloride.
Molecular formula C18H25ClN4O.
CAS No.: 107007-99-8
Activity Granisetron hydrochloride is a potent and selective 5-HT3A channel blocker with Ki~2 nM1.
References-Activity
- Sanger, G.J. and Nelson, D.R. (1989) Eur.J.Pharmacol. 159, 113.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility 50 mg/ml in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Our bioassay
Alomone Labs Granisetron Hydrochloride blocks 5-HT3A receptors expressed in HEK 293T cells.Currents were elicited by 10 µM 5-HT, delivered every 3 minutes. Antagonist Granisetron hydrochloride (#G-105) was applied 30 seconds before stimulation at 1 and 10 nM, as indicated and inhibited the 5-HT induced current in a dose-dependent and reversible manner.
Target 5-Hydroxytryptamine Receptor 3A
Lyophilized Powder
For research purposes only, not for human use
Last Update: 30/03/2021
Specifications
Citations
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