Overview
Alternative Name GYKI47409, (R)-5-(4-amino-3-methyl-phenyl)-8-methyl-7-(5-methyl-1,3,4-thiadiazol-2-yl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine
Structure
Scientific background
GYKI 47409 (BDZ-g) is a potent and selective AMPA receptor antagonist and binds to a noncompetitive site of the receptor. GYKI 47409 inhibits the open channel and the closed-channel conformations of AMPA receptors1.
AMPA receptors are the primary receptors mediating fast excitatory neurotransmission in the mammalian central nervous system. This function is essential for synaptic plasticity, learning and memory1,2.
For research purposes only, not for human use
Specifications
Applications
Our Bioassay
Our bioassay
Alomone Labs GYKI 47409 (BDZ-g) inhibits GluA1 channels expressed in Xenopus oocytes.Representative time course of GluA1 current, activated by a continuous application (top dotted line) of 5 µM (S)-AMPA (#A-267), and inhibited by 1 µM and 10 µM GYKI 47409 (BDZ-g) (#G-245), as indicated (bars), at a holding potential of -80 mV.
Last Update: 08/01/2025
