Synthetic peptide

2-10 nM.

BeKm-1 inhibits ERG1 K⁺ channel currents and has minimal effect on ELK1 K⁺ channels.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

100 nM - 1 μM.

E-4031 is a methsnesulfonanilide class III antiarrhythmic agent. It specifically blocks hERG (K_V11.1) voltage-gated K⁺ channel current in heterologous systems^1,2, cardiac cells³ and cardiac preparations⁴.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to one week at 4°C or six months at -20°C.

Synthetic peptide

10-100 nM.

Ergtoxin-1 is a potent inhibitor of ERG K⁺ channels of nerve, heart and endocrine cells of different species^1,2.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

20-500 nM.

GrTx1 is a blocker of voltage-gated Na⁺ channels and herg1 channels¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

40 nM – 1.3 µM.

GsAF-I is a blocker of TTX-sensitive Na_V and hERG1 channels¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

1-24 µM.

GsAF-II is a blocker of TTX-sensitive Na_V and K_V11.1 channels¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

100-500 nM

Haplotoxin-2 inhibits voltage-gated Na⁺ channels Na_V1.3 as well as K_V11.1 (hERG) channels¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Soluble in water. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

1-100 μM.

NS-1643 is a potent and selective K_V11.1 (hERG, ERG1, erg1) channel modulator (enhancer)¹. NS-1643 was effective in eliciting and enhancing K_V11.1 channels in Xenopus oocytes with apparent EC₅₀ of 20 μM¹. NS-1643 inhibited smooth muscle from bovine epididymal duct contractions with EC₅₀ values of 8 μM². It also potentiates KCNQ2 but not KCNQ1 channels³.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

10-200 µM.

NS-3623 is an opener of K_V11.1 channels with an EC50 of 10.5 μM¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

1-200 µM.

Trimethylapigenin blocks K_V1.5 and hERG channels with IC₅₀ ~ 8 and 30 μM respectively. It also activates CFTR channels¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

50 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).

Up to four weeks at 4°C or three months at -20°C.