Overview
Alomone Labs is pleased to offer the Histamine Receptor Antibody Explorer Kit (#AK-560). The Explorer Kit contains histamine receptor antibodies, ideal for screening purposes.
Compounds
| Product Name | Cat # | Size |
|---|---|---|
Anti-Histamine H1 Receptor (HRH1) Antibody |
AHR-001 | 1 x 50 µl |
Histamine H1 Receptor/HRH1 Blocking Peptide |
BLP-HR001 | 1 x 40 µg |
Anti-Histamine H2 Receptor (HRH2) (extracellular) Antibody |
AHR-002 | 1 x 50 µl |
Histamine H2 Receptor/HRH2 (extracellular) Blocking Peptide |
BLP-HR002 | 1 x 40 µg |
Anti-Histamine H3 Receptor (HRH3) Antibody |
AHR-003 | 1 x 50 µl |
Histamine H3 Receptor/HRH3 Blocking Peptide |
BLP-HR003 | 1 x 40 µg |
Anti-Human Histamine H4 Receptor (HRH4) (extracellular) Antibody |
AHR-004 | 1 x 50 µl |
Human Histamine H4 Receptor/HRH4 (extracellular) Blocking Peptide |
BLP-HR004 | 1 x 40 µg |
Scientific Background
Histamine (2-[4-imidazole]ethylamine) is a low-molecular-weight amine synthesized from L-histidine. It is produced by various cells throughout the body, including central nervous system neurons, gastric mucosa parietal cells, mast cells, basophils and lymphocytes. Histamine is a major biological mediator whose functions include, among many others, regulation of vascular smooth muscle, immune regulation, regulation of sleep-wake cycles and regulation of gastric acid secretion.1
The biological effects of histamine are mediated through four receptors (H1- H4 Histamine receptors) all of which belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily.
- Hill, S.J. (1997) Pharmacol. Rev. 49, 253.
