Overview
Cat #:
I-180
Alternative Name 1-Phenylcyclohexylamine, 4-Amino-4-phenylcyclohexane, PCA, 1-phenylcyclohexan-1-amine
Lyophilized Powder yes
Source Synthetic
MW: 175.27
Purity: >99% (HPLC)
Form Lyophilized Powder
Effective concentration 1-10 µM
Chemical name 1-phenylcyclohexan-1-amine
Molecular formula C12H17N
CAS No.: 2201-24-3
PubChem CID 31862
Activity IEM-1921 is a selective NMDA receptor blocker and is a potent anticonvulsant 1-3.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility Soluble in DMSO
Up to 200 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
Up to 200 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Scientific background
N-methyl-D-aspartate (NMDA) receptors, a family of L-glutamate receptors, play an important role in the central nervous system. Activation of NMDARs leads to cytosolic free intracellular calcium ([Ca2+]i) increase and for synaptic plasticity1.
Abnormal activity of NMDA receptors is associated different neurodegenerative disorders such as Alzheimer’s, Huntington’s, Parkinson’s disease and the etiology of epilepsy1.
IEM-1921, also known as 1-phenylcyclohexylamine, is a selective blocker of NMDA receptors. In chronic experiments on Wistar and Krushinskii–Molodkina rats it was found that IEM-1921 (5mg/kg) acts as anticonvulsant. IEM-1921 decreased the duration of convulsions by 82% and prevent neural abnormalities in the brain2-3.
Target NMDA receptor
Lyophilized Powder
For research purposes only, not for human use
Last Update: 07/05/2024
Specifications
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