Overview
Alternative Name Indisetron hydrochloride
Lyophilized Powder yes
Source Synthetic
MW: 386.31
Purity: >98%.
Effective concentration 10 nM - 1 µM.
Structure
Chemical name N-[(1S,5R)-3,9-dimethyl-3,9-diazabicyclo[3.3.1]nonan-7-yl]-1H-indazole-3-carboxamide;dihydrochloride.
Molecular formula C17H25Cl2N5O.
CAS No.: 160472-97-9
PubChem CID 178038
Activity Indesitron is a specifiic 5-HT3 antagonist, with an IC50 of 23 nM for inhibition of contraction of the guinea-pig colon induced by 2-Me-5-HT1.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility 50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Our bioassay
Alomone Labs Indisetron dihydrochloride blocks 5-HT3A channels expressed in HEK 293T cells.5-HT3A channel currents were elicited by 10 µM 5-HT, delivered every 3 minutes. Indisetron dihydrochloride (#I-175) was applied 30 seconds before stimulation at 100 nM, as indicated and inhibited the 5-HT induced current in a dose dependent and reversible manner.
Target 5-HT3 receptors
Lyophilized Powder
For research purposes only, not for human use
Last Update: 30/03/2021
Specifications
Citations
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