Overview
Alomone Labs is pleased to offer the Intracellular Cl– Channel (CLIC) Antibody Explorer Kit (#AK-410). This Explorer Kit includes intracellular Cl– channel (CLIC) antibodies with their respective peptide control antigen. An ideal tool for screening purposes.
Compounds
| Product Name | Cat # | Size |
|---|---|---|
Anti-CLIC1 Antibody |
ACL-021 | 1 x 50 µl |
CLIC1 Blocking Peptide |
BLP-CL021 | 1 x 40 µg |
Anti-CLIC4 Antibody |
ACL-024 | 1 x 50 µl |
CLIC4 Blocking Peptide |
BLP-CL024 | 1 x 40 µg |
Anti-CLIC5 Antibody |
ACL-025 | 1 x 50 µl |
CLIC5 Blocking Peptide |
BLP-CL025 | 1 x 40 µg |
Scientific Background
Chloride intracellular channel (CLIC) is a family of proteins encoded by six different genes (CLIC1-6)1-3.
The localization of the various CLIC channels remains elusive and controversial since they can be either found in a soluble form in the cytoplasm or as integral membrane proteins (in intracellular compartments such as the nuclear membrane or the endoplasmic reticulum for example, or associate to the plasma membrane) via their single transmembrane domain1.
When membrane associated, CLIC channels indeed function as ion channels (enabling the passage of Cl- ions).
Non-channel functions are also attributed to CLICs and include cell cycle regulation, cell differentiation, and apoptosis. These different roles depend whether CLICs are membrane bound or cytosolic1.
- Edwards, J.C. and Kahl, C.R. (2010) FEBS Lett. 584, 2102.
- Ashley, R.H. (2003) Mol. Membr. Biol. 20, 1.
- Cromer, B.A. et al. (2002) Eur. Biophys. J. 31, 356.
