Overview
Cat #:
STJ-080
Alternative Name JZTX-X, Jingzhaotoxin F7-15.33
Lyophilized Powder yes
Origin Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys jingzhao)
Source Synthetic peptide
MW: 3706 Da
Purity: >98% (HPLC)
Form Lyophilized Powder
Effective concentration 50 – 500 nM
Sequence LCSREGEFCYKLRKCCAGFYCKAFVLHCYRN - OH
Modifications Disulfide bonds location- Cys2-15, Cys9-21 and Cys16-28
Molecular formula C164H242N46O41S6
Activity Jingzhaotoxin-X inhibits the activation of Kv4.2 and Kv4.3 channels and exhibits long-lasting mechanical hyperalgesia in mice1.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C. Protect from light and moisture.
Solubility Soluble in water. Centrifuge all products before use (10000 g, 5 min). It is recommended to prepare fresh solutions in working buffers before use, or aliquot stock solutions reconstituted in distilled water and keep at -20°C. Upon use, dilute the stock solution in the desired working buffer. Prevent repeated thawing and freezing cycles.
Storage of solutions Store up to one week at 4°C or up to 6 months at -20°C.
Scientific background Jingzhaotoxin-X (JZTX-X) is a 31 amino acid peptidyl toxin originally isolated from the venom of the Chinese earth tiger tarantula, Chilobrachys guangxiensis 1,2. JZTX-X is a selective blocker of voltage-gated potassium (Kv)4.2 and Kv4.3 channels2.
Kv channels play key roles in human physiology and pathophysiology. Among the various Kv channels, the Shal-type (Kv4) family is characterized by rapid inactivation and activation, expressing the transient potassium currents within the heart, nervous system, and a subpopulation of smooth muscle cells3. Kv4.2 channel has been identified as a potent factor contributing to the A-type currents within the dorsal horn neurons, and reside at a crucial position for regulating pain processing. Kv4.3 channels are detected within the soma of a neuronal subset of the non-peptidergic nociceptive dorsal root ganglion (DRG), which plays a critical role in the regulation of neuron excitability. Down-regulation of the Kv4.3 channel in pain-sensing neurons can boost pain sensation. JZTX-X toxin was shown to induce long-lasting mechanical hyperalgesia in an animal model2.
Target KV4.2 and KV4.3 Channels
Peptide Content: 100%
Lyophilized Powder
For research purposes only, not for human use
Last Update: 08/01/2025
