Synthetic peptide

100 nM - 1 µM.

Apamin is a blocker of voltage-independent Ca²⁺-activated K⁺ (SK) channels¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or two months at -20°C.

Natural peptide isolated from Dendroaspis angusticeps (Eastern green mamba).

10-500 nM.

β-Dendrotoxin inhibits 4-AP sensitive, inactivating voltage-gated K⁺ channels (K_V1.1, K_V1.2).

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

Natural peptide isolated from Dendroaspis polylepis polylepis (Black mamba).

10-100 nM.

Dendrotoxin-I is a highly selective blocker of voltage-gated K⁺ channels (K_V1.1 and K_V1.2), as well as heteromultimeric channels containing these, with other K_V1 isoforms¹. The inhibition effect is higher in Xenopus oocytes compared to mammalian cells².

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up one week at 4°C or three months at -20°C.

Natural peptide isolated from Dendroaspis polylepis polylepis (Black mamba).

100 nM

Dendrotoxin-K is a highly selective and potent blocker of voltage-gated K⁺ channels K_V1.1 and Kv1.1-containing heterooligomer.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer (pH 7.5). Centrifuge all product preparations before use (10000 x g 5 min).

One week at 4°C or six months at -20°C.

Synthetic peptide

100-500 nM.

Heteropodatoxin-2 is an inhibitor of voltage-gated K⁺ channels of the K_V4 family. Inhibition of K_V4.3 and K_V4.2 is strongly voltage-dependent, while inhibition of K_V4.1 shows less voltage-dependence. Lacks affinity for K_V1.4, K_V2.1 and K_V3.4^1,2. Also blocks Ca²⁺ channels¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to one week at 4°C or three months at -20°C.

Synthetic peptide

0.1-0.2 pM.

Hongotoxin-1 is a potent selective inhibitor of K_V1.1, K_V1.2 and K_V1.3 voltage-gated K⁺ channels and a weak inhibitor of K_V1.6 K⁺ channel. Hongotoxin does not block K_V1.4 nor K_V1.5 currents¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

Synthetic peptide

10 nM - 1 μM.

MCD peptide inhibits K_V1.1 and K_V1.2 channels^1,2.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or six months at -20°C.

100 nM -10 µM.

NS8593 is K_Ca2 (SK) channel blocker, with no activity towards K_Ca3.1 channels, with IC₅₀~100 nM^1,2. It also blocks TRPM7 channels³.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

50 mM DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

Synthetic peptide

10-100 nM.

Phrixotoxin-1 specifically and reversibly blocks K_V4.2 and K_V4.3 channels¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10,000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

20-200 nM.

Scyllatoxin inhibits small conductance Ca²⁺-activated K⁺ channels (SK)^1-3.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

10-100 nM.

Tertiapin blocks a range of inward rectifier K⁺ channels (K_ir) in particular ROMK1 and GIRK but with no effect on K_ir2 family members¹. In addition, it was shown to inhibit acetylcholine induced K⁺ currents in the heart^2,3.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

100 nM.

Tertiapin-LQ is a selective blocker of K_ir1.1 channels.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

2-200 nM.

Tertiapin-Q blocks a range of inward rectifier K⁺ channels (K_ir), in particular ROMK1 and GIRK, but with no effect on K_ir2 family members¹. In addition, it was shown to inhibit acetylcholine induced K⁺ currents in heart^2,3. Tertiapin-Q is a derivative of Tertiapin in which Met¹³ is replaced by Gln. Tertiapin-Q inhibits the above-mentioned channels with similar affinities⁴.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to one week at 4°C or three months at -20°C.

0.1-300 µM.

XE991 blocks KCNQ channels with IC₅₀ of 0.5-10 µM¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Up to 50mM in water. Mild warming or agitation may be required. Spin-down all product preparations before handling.

Up to four weeks at 4°C or three months at -20°C.