Overview
Alomone Labs is pleased to offer the KCa1.1 Channel Modulator Explorer Kit (#EK-132). The Explorer Kit contains KCa1.1 blockers and openers ideal for screening purposes.
Compounds
| Product Name | Cat # | Size |
|---|---|---|
Charybdotoxin |
STC-325 | 1 x 0.1 mg |
Kaliotoxin-1 |
STK-370 | 1 x 0.1 mg |
Iberiotoxin |
STI-400 | 1 x 0.1 mg |
Isopimaric Acid |
I-370 | 1 x 1 mg |
NS-11021 |
N-335 | 1 x 5 mg |
NS-1619 |
N-105 | 1 x 5 mg |
NS19504 |
N-235 | 1 x 5 mg |
Paxilline |
P-450 | 1 x 0.45 mg |
Penitrem A |
P-650 | 1 x 0.65 mg |
Pimaric Acid |
P-270 | 1 x 1 mg |
Slotoxin |
STS-410 | 1 x 0.1 mg |
Tanshinone II-A sodium sulfonate |
T-165 | 1 x 5 mg |
Verruculogen |
V-500 | 1 x 0.51 mg |
Scientific Background
The KCa1.1 channel (also known as BKCa, Maxi K+ or slo) is part of a structurally diverse group of K+ channels that are activated by an increase in intracellular Ca2+. KCa1.1 shows a large single channel conductance when recorded electrophysiologically, hence its name. It differs from the rest of the subfamily members in that it can be activated by both an increase in intracellular Ca2+ and by membrane depolarization. In addition, the KCa1.1 channel structurally differs from the other Ca2+-dependent K+ channels. While the latter group has a topology that resembles that of the voltage-dependent K+ channels, the KCa1.1 channel has an extracellular N-terminus domain as well as an additional transmembrane domain.
KCa1.1 is expressed in virtually all cell types where it causes hyperpolarization and helps to bridge intracellular Ca2+ signaling pathways and membrane excitability.
Indeed, KCa1.1 channels play a crucial role in smooth muscle contractility, neuronal spike shaping and neurotransmitter release.
- Orio, P. et al. (2002) News Physiol. Sci. 17, 156.
- Wallner, M. et al. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 4137.
- Xia, X.M. et al. (1999) J. Neurosci. 19, 5255.
