Overview
Alomone Labs is pleased to offer the KCa2 Channel Modulator Explorer Kit (#EK-122). The Explorer Kit contains KCa2 blockers and openers ideal for screening purposes.
Compounds
| Product Name | Cat # | Size |
|---|---|---|
Apamin |
STA-200 | 1 x 0.5 mg |
CyPPA |
C-110 | 1 x 5 mg |
1-EBIO |
E-150 | 1 x 10 mg |
NS-309 |
N-180 | 1 x 5 mg |
NS-4591 |
N-325 | 1 x 5 mg |
NS8593 hydrochloride |
N-195 | 1 x 5 mg |
Scyllatoxin |
STS-370 | 1 x 0.1 mg |
SKA-31 |
S-120 | 1 x 5 mg |
Tamapin |
STT-400 | 1 x 0.1 mg |
Scientific Background
KCa2 channels are extremely sensitive to the levels of intracellular Ca2+ and concentrations as low as 300-700 nM can open these channels very rapidly (5-15 ms). Hence, the KCa2 channels are highly sensitive and fast Ca2+ sensors, resembling other known Ca2+-binding proteins. This type of Ca2+-dependent activation is achieved by the constitutive binding of the KCa2 channels to calmodulin, a highly expressed Ca2+-binding protein via a calmodulin-binding domain situated at the cytoplasmic C-terminus.
Pharmacologically, the KCa2 channels are the only known targets of the bee venom toxin Apamin, with KCa2.1 being the less sensitive, KCa2.2 the most sensitive and KCa2.3 showing intermediate sensitivity.
- Stocker, M. (2004) Nature Rev. Neurosci. 5, 758.
- Xia, X.M. et al. (1998) Nature 395, 503.
- Kohler, M. et al. (1996) Science 273, 1709.
