Overview
Alomone Labs is pleased to offer the KCNN4 (KCa3.1) Channel Basic Research Pack (#ESB-400). The Research Pack contains all you need for KCa3.1 research: Antibodies recognizing different domains of the channel, specfic KCa3.1 blockers and activators, all in one economical package!
Compounds
| Product Name | Cat # | Size |
|---|---|---|
| Antibodies | ||
Anti-KCNN4 (KCa3.1, SK4) Antibody |
APC-064 | 1 x 0.2 ml |
KCNN4/KCa3.1 Blocking Peptide |
BLP-PC064 | 1 x 40 µg |
Mouse Anti-KCNN4 (KCa3.1, SK4) (extracellular) Antibody |
ALM-051 | 1 x 100 µg |
| Activators/Agonists | ||
1-EBIO |
E-150 | 1 x 25 mg |
SKA-31 |
S-120 | 1 x 10 mg |
| Blockers/Antagonists | ||
NS-6180 |
N-230 | 1 x 10 mg |
TRAM 34 |
T-105 | 1 x 10 mg |
Scientific Background
KCNN4 (KCa3.1) is part of the Ca2+ activated K+ channel family that share the characteristic of being activated by intracellular Ca2+. The channel has an intermediate conductance, is voltage insensitive and is activated by Ca2+ in the submicromolar range. The channel has a similar topology to that of KV channels, that is six transmembrane domains and intracellular N- and C-termini.
KCNN4 is widely expressed in epithelial, endothelial and cells of hematopoietic origin. In erythrocytes (red blood cells) it has been identified as the molecular correlate of the so-called Gardos channel.
The functional role of the channel is to set the cell membrane potential at negative values so as to aid in the electrochemical transport of other ions such as Cl- and Ca2+. Indeed, KCNN4 has a key role in sustaining the Ca2+ influx in activated T lymphocytes and in regulating Cl- secretion from colon epithelium. Therefore, specific blockers of the KCNN4 channel have been proposed for the treatment of several diseases including autoimmune diseases, secretory diarrhea and sickle cell anemia.
- Ghanshani, S. et al. (2000) J. Biol. Chem. 275, 37137.
- Hoffman, J.F. et al. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 7366.
