Overview
Alomone Labs is pleased to offer the KCNQ (KV7) Channel Antibody Explorer Kit (#AK-221). This Explorer Kit includes antibodies targeted against KCNQ channels and subunits along with their respective peptide control antigen. An ideal tool for screening purposes.
Compounds
Scientific Background
The KCNQ family of voltage-gated K+ channels includes 5 known members: KCNQ1 to KCNQ5. Structurally, the KCNQ family belongs to the six transmembrane domain category of K+ channels. KCNQ family members can form either homomultimeric or heteromultimeric channels with different functional consequences. For example, KCNQ2 and KCNQ3 heteromultimers give rise to a much larger channel current than when either protein is expressed alone, probably due to enhanced plasma membrane expression of the combined channel. Indeed, KCNQ2/KCNQ3 heteromultimers are believed to be the molecular correlates of the so-called M current. This current is a K+ neuronal current that is strongly inhibited by the activation of the M1 subtype of the muscarinic acetylcholine receptor. KCNQ5 is also expressed in visceral smooth muscle4 and skeletal muscle.
