Natural peptide isolated from Dendroaspis angusticeps (Eastern green mamba).

10-100 nM.

δ-Dendrotoxin inhibits 4-AP sensitive, inactivating voltage-gated K⁺ channels (K_V1.1, K_V1.2 and K_V1.6). In addition δ-Dendrotoxin inhibits ROMK1 channel currents.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

Recombinant, E. coli

0.1-10 nM.

Lq2 inhibits K_ir1.1 K⁺ inward rectifier channels², as well as K_Ca channels¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

10-100 nM.

Tertiapin blocks a range of inward rectifier K⁺ channels (K_ir) in particular ROMK1 and GIRK but with no effect on K_ir2 family members¹. In addition, it was shown to inhibit acetylcholine induced K⁺ currents in the heart^2,3.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

100 nM.

Tertiapin-LQ is a selective blocker of K_ir1.1 channels.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

2-200 nM.

Tertiapin-Q blocks a range of inward rectifier K⁺ channels (K_ir), in particular ROMK1 and GIRK, but with no effect on K_ir2 family members¹. In addition, it was shown to inhibit acetylcholine induced K⁺ currents in heart^2,3. Tertiapin-Q is a derivative of Tertiapin in which Met¹³ is replaced by Gln. Tertiapin-Q inhibits the above-mentioned channels with similar affinities⁴.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to one week at 4°C or three months at -20°C.

0.1-25 µM.

VU590 inhibits ROMK1 channels in a dose-dependent manner with an IC₅₀ of 294 nM. Inhibits K_ir7.1 at micromolar concentrations, whilst having no effect on K_ir2.1 or K_ir4.1¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Up to 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

0.1-50 µM.

VU591 is a K_ir1.1 channel blocker¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

10 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.