Mouse, dog, human, - identical.

Mouse - identical; human - 12/13 amino acid residues identical.

Synthetic peptide

30 nM.

κ-Conotoxin RIIIJ is a blocker of K_V1.2 channels¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Natural peptide isolated from Dendroaspis polylepis polylepis (Black mamba).

100 nM

Dendrotoxin-K is a highly selective and potent blocker of voltage-gated K⁺ channels K_V1.1 and Kv1.1-containing heterooligomer.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer (pH 7.5). Centrifuge all product preparations before use (10000 x g 5 min).

One week at 4°C or six months at -20°C.

Synthetic peptide

10 nM - 1 μM.

MCD peptide inhibits K_V1.1 and K_V1.2 channels^1,2.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or six months at -20°C.

Synthetic peptide

0.5 - 50 nM.

Tityustoxin-Kα blocks cloned K_V1.2 with high potency¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

0.5-50 nM.

Tityustoxin-Kα blocks cloned K_V1.2 with high potency^1,2.
Using Alomone labs Tityustoxin-Kα-ATTO Fluor-594 in microscopy technique, Williams R.W. et al. showed recently that stimulating adenylate cyclase (AC) decreased surface K_V1.2 within the pinceaus of cerebellar basket cell (BC) axon terminals³.

The product is lyophilized in 0.5 ml conical vial.
Centrifuge the vial before adding solvent (10,000 x g for 5 minutes). The lyophilizate may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed.
Soluble in pure water at high-micromolar concentrations (50 µM - 1 mM). For long-term storage in solution, it is recommended to prepare a stock solution by dissolving the product in double distilled water (ddH₂O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations at 10,000 x g for 5 minutes before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity. Avoid exposure to light.