10 µM.

2,5-dimethylcelecoxib is a KCNQ channel opener in smooth muscle cells¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

0.5-50 µM.

ICA-27243 is a potent and selective KCNQ channel modulator (enhancer)¹ with EC₅₀ ~ 1 µM.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

100 mM DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

0.1-10 µM.

ICA-110381 is a KCNQ channel opener with anti-convulsive properties¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

200 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

0.1-300 µM.

Linopirdine blocks KCNQ channels with an IC₅₀ of 2.4 μM for K_V7.2/3 heteromers¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

100 mM in water. Centrifuge all product preparations before use (10000 x g for 1 min).

Up to four weeks at 4°C or three months at -20°C.

1-100 μM.

NS-1643 is a potent and selective K_V11.1 (hERG, ERG1, erg1) channel modulator (enhancer)¹. NS-1643 was effective in eliciting and enhancing K_V11.1 channels in Xenopus oocytes with apparent EC₅₀ of 20 μM¹. NS-1643 inhibited smooth muscle from bovine epididymal duct contractions with EC₅₀ values of 8 μM². It also potentiates KCNQ2 but not KCNQ1 channels³.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

1-100 µM.

QO-40 is a KCNQ channel opener with EC₅₀ of ~7 µM on cloned channels and on native M-current in DRG neurons¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

200 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

0.1-100 µM

Retigabine is a potent and selective KCNQ (K_V7, M-) channel modulator (enhancer)¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Water. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

0.1-300 µM.

XE991 blocks KCNQ channels with IC₅₀ of 0.5-10 µM¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Up to 50mM in water. Mild warming or agitation may be required. Spin-down all product preparations before handling.

Up to four weeks at 4°C or three months at -20°C.