Overview
- Priestley, T. et al. (1996) Neuropharmacol. 35, 1573.
- Traynelis S. F. et al. (2010) Pharmacol. Rev., 62, 405,
Soluble in DMSO. It is recommended to prepare fresh solutions before use. Centrifuge all products before use (10000 x, g 5 min). Avoid multiple freezing and thawing.
Alomone Labs L-701,324 inhibits NMDA (NR1+NR2A) receptors expressed in Xenopus oocytes.A. Representative time course of NR1/NR2A currents, elicited by transient stimulations with 2
µM glutamate + 10 µM glycine every 50 sec, while membrane potential was held at -80 mV, and significantly inhibited by 5 nM L-701,324 (#L-195).
B. Superimposed current traces from the recording shown in A, following application of control and 5 nM L-701,324. Transient stimulation is indicated by an arrow.
- Vyklicky, V. et al. (2014) Physiol. Res., 63, S191.
- Obrenovitch, T. P. et al. (1996) Br. J. Pharmacol., 117, 931.
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- Liu, L. et al. (2021) Behav. Brain Res., 399, 113038.
Glutamate is a central excitatory neurotransmitter in the nervous system and his mediating signaling is important for basic neuron-to-neuron signaling and neuronal processes such as learning, memory and pain perception. N-methyl-D-aspartate (NMDA) receptor are the major subtype of glutamate receptors that participate in synaptic transmission. NMDA receptor consists of three different subunits termed GluN1-3. Activation of NMDA receptor carried out via interaction with glycine and glutamate1.
L-701,324 (7-chloro-4-hydroxy-3(3-phenoxy) phenylquinoline-2-(H)-on) is an effective NMDA antagonist that antagonizes the activity of the NMDA receptor by blocking its glycine binding site. It was found that L-701,324 when administered orally has an inhibitory effect on spreading depression (SD) initiations and propagation2. Moreover L-701,324 act as anticonvulsant and neuroprotective agent3. Recently it was shown that antidepressant effect of L-701,324 in mice IS mediated by elevating the hippocampal BDNF signaling cascade4.
L-701,324 (#L-195) is a highly pure, synthetic and biologically active compound.
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