L-701,324

Applications
Specifications
Scientific Background

Overview

Cat #: L-195

Purity: >97%

CAS No.: 142326-59-8

MW: 363.8

Form: Lyophilized

L-701,324 (#L-195) is a highly pure, synthetic and biologically active compound.

Certificate of Analysis SDS

Alternative Name 7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinone

Structure

For research purposes only, not for human use

Applications

Specifications

Properties

Technical Specifications

MW 363.8

Purity >97%

Molecular formula C₂₁H₁₄CINO₃

Form Lyophilized Powder

CAS No. 142326-59-8

Source Synthetic

PubChem CID 54682505

Chemical name 7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinone

Biological Activity

Target NMDA receptor

Effective concentration 2 nM – 0.1 µM

Activity L-701,324 is a potent and selective NMDA receptor antagonist that acts at the glycine site^1,2.

References

Priestley, T. et al. (1996) Neuropharmacol. 35, 1573.
Traynelis S. F. et al. (2010) Pharmacol. Rev., 62, 405,

Solubility and Storage

Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C. Protect from light and moisture.

Solubility

Soluble in DMSO. It is recommended to prepare fresh solutions before use. Centrifuge all products before use (10000 x, g 5 min). Avoid multiple freezing and thawing.

Storage of solutions Store up to four weeks at 4°C or three months at -20°C.

Scientific Background

Scientific background

Glutamate is a central excitatory neurotransmitter in the nervous system and his mediating signaling is important for basic neuron-to-neuron signaling and neuronal processes such as learning, memory and pain perception. N-methyl-D-aspartate (NMDA) receptor are the major subtype of glutamate receptors that participate in synaptic transmission. NMDA receptor consists of three different subunits termed GluN1-3. Activation of NMDA receptor carried out via interaction with glycine and glutamate¹.
L-701,324 (7-chloro-4-hydroxy-3(3-phenoxy) phenylquinoline-2-(H)-on) is an effective NMDA antagonist that antagonizes the activity of the NMDA receptor by blocking its glycine binding site. It was found that L-701,324 when administered orally has an inhibitory effect on spreading depression (SD) initiations and propagation². Moreover L-701,324 act as anticonvulsant and neuroprotective agent³. Recently it was shown that antidepressant effect of L-701,324 in mice IS mediated by elevating the hippocampal BDNF signaling cascade⁴.