Overview
Alternative Name Lamictal, Lamotriginum
Lyophilized Powder yes
Source Synthetic
MW: 256.1
Purity: ≥97%.
Effective concentration 10-300 µM.
Structure
Chemical name 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine.
Molecular formula C9H7Cl2N5.
CAS No.: 84057-84-1
PubChem CID 3878
Activity Lamotrigine has an apparent KD value for inactivated-state block of rat brain NaV1.2 sodium channels expressed in Xenopus oocytes of 31.9 μM1.
References-Activity
- Liu, G. et al. (2003) Neuropharmacology 44, 413.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Our bioassay
Alomone Labs Lamotrigineblocks NaV1.2 channels expressed in Xenopus oocytes.A. Time course of NaV1.2 current amplitude and inhibition by 100 and 300 µM Lamotrigine (#L-205). Currents were elicited by application of a 100 ms voltage step to 0 mV (H.P= -50 mV, to induce inactivation), every 10 seconds. B. Superimposed example traces of current responses before and during perfusion of 100 and 300 µM Lamotrigine, as indicated.
Target NaV1.2 channels
Lyophilized Powder
For research purposes only, not for human use
Last Update: 30/03/2021
Specifications
Citations
Citations
