Overview
Alternative Name Cozaar, Lorzaar, Losaprex
Lyophilized Powder yes
Source Synthetic
MW: 461
Purity: ≥99%.
Effective concentration 1-100 nM.
Structure
Chemical name potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,3-triaza-4-azanidacyclopenta-2,5-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol.
Molecular formula C22H22ClKN6O.
CAS No.: 124750-99-8
PubChem CID 11751549
Activity Losartan potassium is an Angiotensin II Type 1 receptor antagonist1.
References-Activity
- Ji, H. et al. (1994) J. Biol. Chem. 269, 16533.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility 200 mM in H2O or DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Our bioassay
Alomone Labs Losartan potassium inhibits the activation of AT1R expressed in CHO-K1-mt aequorin-Gα16 cells.Dose-response curve for the inhibition of AT1R expressed in CHO-K1-mt aequorin-Gα16 cells. Ca2+ response, as detected by elevation in aequorin derived fluorescence following 0.04 nM Angiotensin II application, was inhibited by increasing concentrations of Losartan potassium (#L-185). 20 nM Losartan potassium fully inhibited the activation by Angiotensin II.
Target AT1R receptors
Lyophilized Powder
For research purposes only, not for human use
Last Update: 30/03/2021
Specifications
Citations
Citations
