Overview
Alomone Labs is pleased to offer the Lysophospholipid (LPA) Receptor Antibody Explorer Kit (#AK-515). The Explorer Kit contains lysophospholipid (LPA) receptor antibodies, ideal for screening purposes.
Compounds
| Product Name | Cat # | Size |
|---|---|---|
Anti-LPAR1 (EDG2) (extracellular) Antibody |
ALR-031 | 1 x 50 µl |
LPAR1/EDG2 (extracellular) Blocking Peptide |
BLP-LR031 | 1 x 40 µg |
Anti-LPAR2 (EDG4) (extracellular) Antibody |
ALR-032 | 1 x 50 µl |
LPAR2/EDG4 (extracellular) Blocking Peptide |
BLP-LR032 | 1 x 40 µg |
Anti-LPAR3 (EDG7) (extracellular) Antibody |
ALR-033 | 1 x 50 µl |
LPAR3/EDG7 (extracellular) Blocking Peptide |
BLP-LR033 | 1 x 40 µg |
Anti-LPAR4 (P2Y9) (extracellular) Antibody |
ALR-034 | 1 x 50 µl |
LPAR4/P2Y9 (extracellular) Blocking Peptide |
BLP-LR034 | 1 x 40 µg |
Anti-Human LPAR5 (extracellular) Antibody |
ALR-035 | 1 x 50 µl |
Human LPAR5 (extracellular) Blocking Peptide |
BLP-LR035 | 1 x 40 µg |
Anti-LPAR6 (P2RY5) (extracellular) Antibody |
ALR-036 | 1 x 50 µl |
LPAR6/P2RY5 (extracellular) Blocking Peptide |
BLP-LR036 | 1 x 40 µg |
Scientific Background
Lysophosphatidic acid (LPA; 1- or 2-acyl-sn-glycerol-3-phosphate) is a bioactive lipid molecule with a phosphate, a glycerol, and a fatty acid in its structure. The cellular effects of LPA include proliferation, migration, cytokine secretion, and morphological change. These pleiotropic actions allow LPA to participate in a wide variety of biological processes, such as brain development, oncogenesis, wound healing and cancer progression1. To date, at least 6 subtypes of LPA receptor have been identified. The LPA1-3 receptors are members of the endothelial cell differentiation gene (Edg) family2.
LPA6 (P2Y5) was cloned as an orphan GPCR and is closely related to the fourth lysophosphatidic acid receptor, LPA43. GPCRs share a similar topology, with seven transmembrane helices (TMHs) connected by three extracellular loops (ECLs), and three intracellular loops (ICLs); the N terminus is on the extracellular side of the membrane, and the C terminus is on the cytoplasmic side4.
LPA6 mRNA is expressed ubiquitously including in skin and hair follicle cells.
A recent study suggested that LPA6 is essential for human hair growth. A loss of function is not compensated for, and ultimately leads to pathological changes and hair loss5.
- Yun, C.C. et al. (2005) Am. J. Physiol. 289, C2.
- Feng, Y. et al. (2014) Exp. Ther. Med. 7, 423.
- Knowlden, S. et al. (2013) Atlas of Genetics and Cytogenetics in Oncology and Haematology 17, 259.
- Contos, J.J. et al. (2002) Mol. Cell. Biol. 22, 6921.
- Fang, X. et al. (2000) Ann. N.Y. Acad. Sci. 905, 188.
