Overview
Alternative Name DDP-225
Lyophilized Powder yes
Source Synthetic
MW: 328.4
Purity: >98%
Effective concentration 10 nM - 1 µM.
Structure
Chemical name 4-(2-fluorophenyl)-6-methyl-2-piperazin-1-ylthieno[2,3-d]pyrimidine.
Molecular formula C17H17FN4S.
CAS No.: 135991-48-9
PubChem CID 131927
Activity MCI-225 shows high affinity for the 5-HT3 receptor, Ki less than 100 nmol/L1.
References-Activity
- Eguchi, J. et al. (2001) Pharmacol. Biochem. Behav. 68, 677.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility 30 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Our bioassay
Alomone Labs MCI-225 blocks 5-HT3A receptors expressed in HEK 293T cells.5-HT3A receptor currents were elicited by 10 µM 5-HT, delivered every 3 minutes. MCI-225 (#M-190) was applied 30 seconds before stimulation at 10 and 100 nM, as indicated and inhibited the 5-HT induced current in a dose-dependent and reversible manner.
Scientific background
MCI-225 is a psychoactive compound, a thienopyrimidine analogue that acts as a selective noradrenaline (NA) reuptake inhibitor with 5-HT3 channel blocking action. The compound demonstrates antidepressant-like activity with primary activity in the central nervous system.
Several studies have shown that MCI-225 exhibits improvement in amnesia in scopolamine treated rats and in basal forebrain lesion rats. Acute administration of MCI-225 inhibits the rise of threshold induced by footshock stress1.
It has been suggested that MCI-225 may affect attention, learning and memory2.
Target 5-HT3A receptor, NET transporter
Lyophilized Powder
For research purposes only, not for human use
Last Update: 07/05/2024
Specifications
Citations
Citations
