Overview
Alternative Name Inversine, Mevasin, 826-39-1, Mekamin hydrochloride, Mecamine hydrochloride, EINECS 212-555-8
Lyophilized Powder yes
Source Synthetic
MW: 203.75
Purity: >99.5%.
Form Lyophilized powder.
Effective concentration 50 nM – 10 µM.
Structure
Chemical name N,2,2,3-tetramethylbicyclo[2.2.1]heptan-3-amine;hydrochloride.
Molecular formula C11H22ClN.
CAS No.: 826-39-1
Activity Mecamylamine blocks nAChRs with IC50s ~ 400 nM for α3/β4 and ~ 7 µM for α7 nicotinic channels1.
References-Activity
- Papke, R.L. et al. (2001) J. Pharmacol. Exp. Ther. 297, 646.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility Water. Centrifuge all product preparations before use (10000 x g for 1 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Our bioassay
Alomone Labs Mecamylamine hydrochloride reversibly inhibits nicotinic receptors heterologously expressed in Xenopus oocytes.A. Time course of the inhibitory effect of 1 and 10 µM Mecamylamine hydrochloride (#M-105) on α7 nicotinic currents, elicited at -80 mV holding potential by continuous stimulation with 100 µM ACh + 3 µM PNU 282987 (#P-110) every 50 sec (indicated by uppermost horizontal bars). B. Superimposed traces of channel activity before and during application of the indicated Mecamylamine hydrochloride concentrations (taken from the experiment shown in panel A).
Target nAChR
Lyophilized Powder
For research purposes only, not for human use
Last Update: 30/03/2021
Specifications
Citations
Citations
