Overview
Alternative Name Namenda, Axura
Lyophilized Powder yes
Source Synthetic
MW: 215.8
Purity: >99%.
Effective concentration 100 nM - 10 µM.
Structure
Chemical name 3,5-dimethyladamantan-1-amine;hydrochloride.
Molecular formula C12H22ClN.
CAS No.: 41100-52-1
PubChem CID 181458
Activity Memantine is an NMDA receptor antagonist. IC50 = 0.8 μM (NR2A), 0.5 μM (NR2B), 0.5 μM (NR2C), 0.5 μM (NR2D)1.
References-Activity
- Johnson, J.W. et al. (2006) Curr. Opin. Pharmacol. 6, 61.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility 100 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Our bioassay
Alomone Labs Memantine hydrochloride inhibits NMDA (NR1+NR2A) channels expressed in Xenopus oocytes.A. Time course of NMDA currents elicited 100 µM glutamate every 50s, while membrane potential was held at -80 mV. 1 and 10 µM Memantine hydrochloride (#M-145), applied for 2 min each, as indicated, reversibly inhibited current amplitude. B. superimposed current traces taken from the experiment described in A.
Target NMDA receptors
Lyophilized Powder
For research purposes only, not for human use
Last Update: 30/03/2021
Specifications
Citations
Citations
