Overview
Cat #: AK-445_KIT
Size: 9 Vials
Form: Lyophilized
Alomone Labs is pleased to offer the Monoamine Transporter Antibody Explorer Kit (#AK-445). The Explorer Kit contains monoamine transporter antibodies, ideal for screening purposes.
For research purposes only, not for human use
Compounds
| Product Name | Cat # | Size |
|---|---|---|
Dopamine Transporter/DAT (extracellular) Blocking Peptide |
BLP-MT003 | 1 x 40 µg |
Anti-Noradrenaline Transporter (NET) (extracellular) Antibody |
AMT-002 | 1 x 50 µl |
Noradrenaline Transporter/NET (extracellular) Blocking Peptide |
BLP-MT002 | 1 x 40 µg |
Anti-Serotonin Transporter (SERT) (extracellular) Antibody |
AMT-004 | 1 x 50 µl |
Serotonin Transporter/SERT (extracellular) Blocking Peptide |
BLP-MT004 | 1 x 40 µg |
Anti-VMAT1 Antibody |
AMT-007 | 1 x 50 µl |
VMAT1 Blocking Peptide |
BLP-MT007 | 1 x 40 µg |
Anti-VMAT2 Antibody |
AMT-006 | 1 x 50 µl |
VMAT2 Blocking Peptide |
BLP-MT006 | 1 x 40 µg |
Scientific Background
Scientific Background Many physiological, endocrine and behavioral functions are determined and regulated by monoamine signaling1,2. Many brain disorders such as depression, drug abuse, schizophrenia, attention deficit hyperactivity disorder (ADHD) are caused by the malfunction of monoaminergic transmission1-3. The intensity of monoaminergic signaling is determined by the availability of the monoamine, which is in turn determined in part by its uptake from the extracellular milieu via monoamine transporters. These transporters include DAT, SERT, and NET, responsible for uptaking dopamine, serotonin and noradrenaline respectively, and recycling them back for release3-5.
References
- Ramamoorthy, S. et al. (2010) Pharmacol. Ther. 129, 220.
- Siuta, M.A. et al. (2010) PLoS Biol. 8, e1000393.
- Madras, B.K. et al. (2005) Biol. Psychiatry 57, 1397.
- Gainetdinov, R.R. and Caron, M.G. (2003) Annu. Rev. Pharmacol. Toxicol. 43, 261.
- Moron, J.A. et al. (2002) J. Neurosci. 22, 389.
