Overview
Mouse BV-2 Microglia Antibody Explorer Kit (#AK-675) is a budget friendly screening package.
Compounds
| Product Name | Cat # | Size |
|---|---|---|
Anti-GPR34 (extracellular) Antibody |
AGR-055 | 1 x 50 µl |
GPR34 (extracellular) Blocking Peptide |
BLP-GR055 | 1 x 40 µg |
Anti-P2Y12 Receptor (extracellular) Antibody |
APR-020 | 1 x 50 µl |
P2Y12 Receptor (extracellular) Blocking Peptide |
BLP-PR020 | 1 x 40 µg |
Anti-P2Y2 Receptor (extracellular) Antibody |
APR-102 | 1 x 50 µl |
P2Y2 Receptor (extracellular) Blocking Peptide |
BLP-PR102 | 1 x 40 µg |
Anti-P2Y6 Receptor (extracellular) Antibody |
APR-106 | 1 x 50 µl |
P2Y6 Receptor (extracellular) Blocking Peptide |
BLP-PR106 | 1 x 40 µg |
Anti-TREM2 (extracellular) Antibody |
ANR-018 | 1 x 50 µl |
TREM2 (extracellular) Blocking Peptide |
BLP-NR018 | 1 x 40 µg |
Anti-mGluR5 (extracellular) Antibody |
AGC-007 | 1 x 50 µl |
mGluR5 (extracellular) Blocking Peptide |
BLP-GC007 | 1 x 40 µg |
Scientific Background
Microglia are the resident immune cells of the central nervous system that mediate an array of critical functions like neuronal development and connectivity as well as protecting their environment from unwelcome invaders1,4. On the other hand, microglia are also implicated in a variety of inflammatory and neurological disorders such as Alzheimer's disease, epilepsy, and schizophrenia3.
More recently, interest in microglia has resurfaced after numerous studies found them important in regulating neuronal connectivity2. These studies also demonstrated that microglia cells could form synaptic connections between neurons during embryonic stage or during synaptic plasticity processes to enhance neuronal function2.
BV-2 cell line originating from mouse is a common cell model used to study microglia.
- Eyo, U.B. and Wu, L.J. (2019) Prog. Neurobiol. 179, 101614.
- Ikegami, A. et al. (2019) Neuropathology 39, 173.
- Salter, M.W. and Stevens, B. (2017) Nat. Med. 23, 1018.
- Wolf, S.A. et al. (2017) Annu. Rev. Physiol. 79, 619.
