Overview
Cat #:
STC-130
Alternative Name Mu-conotoxin SxIIIC, SxIIIC peptide
Lyophilized Powder yes
Origin Conus striolatus (Cone snail)
Source Synthetic peptide
MW: 2437 Da
Purity: >98%
Form Lyophilized Powder
Effective concentration 15 – 200 nM
Sequence RGCCNGRGGCSSRWCRDHARCC-NH2
Modifications Disulfide bonds location - Cys3-Cys15, Cys4-Cys21 and Cys10-Cys22
Cys22 - Cysteine amide
Molecular formula C90H141N41O28S6
Activity Mu-conotoxin SxIIIC most potently blocks NaV1.4 channel, with 10-fold selectivity over NaV1.1, 1.3, 1.6 and 1.7, 24-fold selectivity over hNaV1.2.
Accession number A0A7M4DUE8 Shipping and storage The product is shipped as a lyophilized powder at room temperature. Upon receipt, it should be stored at -20°C. Protect from moisture.
Solubility Soluble in water. For long-term storage in solution, we recommend to prepare a stock solution by dissolving the product in ddH2O at a concentration X100-1000 of final working solution. Divide the solution into small aliquots and store at -20°C. Upon use, thaw the relevant vial intended for use and dilute in your desired working buffer. The preparation of fresh solutions in working buffers before use is recommended. Repeat freeze-thawing might result in loss of activity. Centrifuge all product preparations before use (10000 x g, 5 min).
Storage of solutions The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the toxin in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.
Scientific background µ-conotoxin SxIIIC (SxIIIC) is a 22 amino acid peptidyl toxin originally isolated from the venom of the cone snail, Conus striolatus1. SxIIIC is a potent and irreversible blocker of voltage-gated sodium (Nav) channels, which displays a unique µ-conotoxin selectivity profile of human (h)NaV1.4 > hNaV1.3 > hNaV1.1 ≈ hNaV1.6 ≈ hNaV1.7 > hNaV1.2 >> hNaV1.5 ≈ hNaV1.81.
Voltage-gated sodium channels (VGSCs) are transmembrane proteins that control the voltage-dependent increase in sodium permeability. VGSCs play a fundamental role in normal neurological function, especially in the initiation and propagation of action potentials. Nav channels have been the topic of significant research and discussion for a considerable amount of time given their unique functions in electrical cell signaling. These channels are very important for homeostasis, thus specific genetic abnormalities in VGSC genes can result in a range of muscle, cardiac, and neurological disorders known as “channelopathies”2. Marine toxins appear to be an emerging source of therapeutic tools that can relieve pain or treat VGSC-related human channelopathies3.
Target Nav1.4, Nav1.3, Nav1.1, Nav1.6 and Nav1.7 blocker
Peptide Content: 100%
Lyophilized Powder
For research purposes only, not for human use
Last Update: 07/05/2024
