Overview
Alomone Labs is pleased to offer the Muscarinic Receptor Antibody Explorer Kit (#AK-206). The Explorer Kit contains muscarinic receptor antibodies. An ideal tool for screening purposes.
Compounds
| Product Name | Cat # | Size |
|---|---|---|
Anti-CHRM1 Antibody |
AMR-001 | 1 x 50 µl |
CHRM1 Blocking Peptide |
BLP-MR001 | 1 x 0.15 mg |
Anti-CHRM1 (443-458) Antibody |
AMR-010 | 1 x 50 µl |
CHRM1 (443-458) Blocking Peptide |
BLP-MR010 | 1 x 40 µg |
Anti-CHRM2 Antibody |
AMR-002 | 1 x 50 µl |
CHRM2 Blocking Peptide |
BLP-MR002 | 1 x 0.12 mg |
Anti-CHRM3 Antibody |
AMR-006 | 1 x 50 µl |
CHRM3 Blocking Peptide |
BLP-MR006 | 1 x 40 µg |
Anti-CHRM4 Antibody |
AMR-004 | 1 x 50 µl |
CHRM4 Blocking Peptide |
BLP-MR004 | 1 x 40 µg |
Anti-CHRM5 (extracellular) Antibody |
AMR-005 | 1 x 50 µl |
CHRM5 (extracellular) Blocking Peptide |
BLP-MR005 | 1 x 40 µg |
Scientific Background
The action of the neurotransmitter acetylcholine is mediated through two types of receptors, the ionotrophic nicotinic receptors and the metabotrophic muscarinic receptors. The muscarinic receptors belong to the superfamily of 7-TM G-protein-coupled receptors. Five subtypes of muscarinic receptors have been cloned and named m1-m5.1-2
The muscarinic receptors are widely distributed throughout the body, but are predominantly expressed within the parasympathetic nervous system and exerts both excitatory and inhibitory control over central and peripheral tissues.1-2
Muscarinic receptors participate in a number of physiological functions such as regulation of heart rate, muscle contraction, cognition, sensory processing and motor control.1 They also participate in learning and memory processing.3-4 The m1 receptors are the most abundant muscarinic subtype in the cortex and striatum. m1 receptors were also localized in the myenteric plexus where they function as autoreceptors to enhance the release of Ach from the nerves.5-6
- Felder, C.C. et al. (2000) J. Med. Chem. 43, 4333.
- Forsythe, S.M. et al. (2002) Am. J. Respir. Cell. Mol. Biol. 26, 298.
- Ferreira, A.R. et al. (2003) Pharmacol. Biochem. Behav. 74, 411.
- Van der Zee, E.A. et al. (1999) Prog. Neurol. 58, 409.
- Levey, A.I. et al. (1991) J. Neurosci. 11, 3218.
- Wang, J. et al. (2000) Am. J. Physiol. 279, G1059.
