0.5-200 µM.

DMPP activates α4 nicotinic channels expressed in Xenopus oocytes with IC₅₀ 0.77 μM¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Water. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

40 nM - 1 μM.

(-)-Cytisine is a potent and selective agonist of neuronal nAChR. It acts as a partial agonist at β2-containing nAChR^1,2.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer (up to 100mM stock). Centrifuge all product preparations before use (10000 x g 5 min).

Up to one week at 4°C or six months at -20°C.

0.1-10 µM.

DMAB-anabaseine dihydrochloride is a partial agonist of α7 nicotinic acetylcholine receptors (nAChR) and antagonist of α4/β2 nAChR¹. It blocks the acetylcholine induced α7 current with IC₅₀ ~5 µM². DMAB-anabaseine dihydrochloride can also displace isotopic (-)-cytisine and α-bungarotoxin binding to rat brain membranes with high affinity³.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to one week at 4°C or six months at -20°C.

0.5-200 µM.

(-)-Nicotine ditartrate activates α7 nAChR with EC₅₀ ~25 µM¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Water. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

0.3-10 µM.

PNU-120596 is a potent and selective type-II positive allosteric modulator of α7 nicotinic acetylcholine receptors, shown to potentiate α7 currents in X. Laevis oocytes and in SH-EP1 cells with EC₅₀ values of 1.6 µM and 216 nM, respectively^1-2. Neuroprotective in vivo³.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at +4°C.

Soluble to 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Store at -20°C. It is recommended to prepare solutions afresh on the day of use, or aliquot stock solutions stored at -20°C to prevent repeated thawing and freezing.

EC₅₀ ~ 5 μM.

PNU 282987 is a selective agonist of α7 nicotinic acetylcholine receptor (nAChR)^1-2, with an EC₅₀ of 5.6 μM in Xenopus oocytes³ and K_i of 26 nM in rat α7 nAChR¹. Via modulating/enhancing hippocampal GABAergic neurotransmission, PNU 282987 improves auditory gating and enhances hippocampal oscillatory activity and therefore may offer a potential pharmacotherapy in the treatment of schizophrenia¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to one week at 4°C or three months at -20°C.

1-100 µM.

RJR 2403 oxalate activates α4/β2 nAChR EC₅₀ ~ 16 μM¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Water. Centrifuge all product preparations before use (10000 x 1 min).

Up to four weeks at 4°C or three months at -20°C.