Natural peptide isolated from Bungarus multicinctus (Many-banded krait).

1 nM - 3 μM.

α-Bungarotoxin blocks postsynaptic neuromuscular transmission via competitive inhibition of nicotinic ACh receptors (nAChRs), thereby preventing the depolarizing action on postsynaptic membranes and blocking neuromuscular transmission. Selective for α7 receptors (IC₅₀ value of 1.6 nM) and α3/β4 receptors (IC₅₀ value of >3 μM)^1,2. The toxin also blocks GABA(A) receptor subtypes³.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

5 -20 µM.

α-Conotoxin AuIA is a blocker of α3/β4 nAChR subtypes¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

1-20 nM

αA-Conotoxin PIVA reversibly blocks muscle α1/β1/γ/δ nicotinic ACh receptor^1,2.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

0.5-1 µM.

µ-Conotoxin CnIIIC blocks Na_V channels and α3/β2 nAChRs.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

0.1-10 μM

α-Conotoxin ImI potently and specifically blocks mammalian neuronal nAChR (α3/β2 > α7 > α3/β4)¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

40 nM - 1 μM.

(-)-Cytisine is a potent and selective agonist of neuronal nAChR. It acts as a partial agonist at β2-containing nAChR^1,2.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer (up to 100mM stock). Centrifuge all product preparations before use (10000 x g 5 min).

Up to one week at 4°C or six months at -20°C.

0.1-10 µM.

DMAB-anabaseine dihydrochloride is a partial agonist of α7 nicotinic acetylcholine receptors (nAChR) and antagonist of α4/β2 nAChR¹. It blocks the acetylcholine induced α7 current with IC₅₀ ~5 µM². DMAB-anabaseine dihydrochloride can also displace isotopic (-)-cytisine and α-bungarotoxin binding to rat brain membranes with high affinity³.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to one week at 4°C or six months at -20°C.

0.1-100 µM.

(-)-Lobeline hydrochloride is a high affinity modulator of nicotinic acetylcholine receptors. It inhibits α7 nAChRs with IC₅₀ of 8.5 µM¹.
It also acts on the α4/β2 combination².

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Ethanol/water. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

0.5-200 µM.

(-)-Nicotine ditartrate activates α7 nAChR with EC₅₀ ~25 µM¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Water. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

EC₅₀ ~ 5 μM.

PNU 282987 is a selective agonist of α7 nicotinic acetylcholine receptor (nAChR)^1-2, with an EC₅₀ of 5.6 μM in Xenopus oocytes³ and K_i of 26 nM in rat α7 nAChR¹. Via modulating/enhancing hippocampal GABAergic neurotransmission, PNU 282987 improves auditory gating and enhances hippocampal oscillatory activity and therefore may offer a potential pharmacotherapy in the treatment of schizophrenia¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to one week at 4°C or three months at -20°C.

1-100 µM.

RJR 2403 oxalate activates α4/β2 nAChR EC₅₀ ~ 16 μM¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Water. Centrifuge all product preparations before use (10000 x 1 min).

Up to four weeks at 4°C or three months at -20°C.