10 nM - 10 μM.

A-803467 is a potent and selective blocker of the TTX-resistant Na_V1.8 channel. A-803467 is a state dependent inhibitor with IC₅₀ of 8 nM at depolarized membrane potential (-40 mV) and 80 nM at -100 mV. As an efficient inhibitor of TTX-resistant currents in DRG neurons, A-803467 was also effective as an analgesic in several rodent models of different pathological pain states^1,2. A-803467 was used as a pharmacological tool to demonstrate the expression of Na_V1.8 in the heart conduction system and its contribution to QRS interval in the mouse heart³.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

Synthetic peptide

20-500 nM.

Huwentoxin-IV specifically inhibits the neuronal tetrodotoxin-sensitive (TTX-S) voltage-gated Na⁺ channel (IC₅₀ = 30 nM) in adult rat dorsal root ganglion neurons, while having no significant effect on the tetrodotoxin-resistant (TTX-R) voltage-gated Na⁺ channel^1-3.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

3-100 nM.

m3-Huwentoxin IV is a mutated form of the Huwentoxin IV with significant increased potency towards Na_V1.7, displaying an IC₅₀ value of 0.4 nM¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g for 5 min).

Up to two weeks at 4°C or three months at -20°C.

10 nM - 1 µM.

ICA 121431 blocks Na_V channels with IC₅₀ values of 13 and 23 nM for Na_V1.3 and Na_V1.1 respectively¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

10 nM - 1 µM.

N-Me-aminopyrimidinone 9 is a Na_V1.7 channel blocker with IC₅₀ value of 100 nM for Na_V1.7 channels in their inactivated state¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

Synthetic peptide

10-100 nM.

ProTx-I inhibits voltage-gated Ca²⁺ (Ca_V3.1), K⁺ (K_V2.1), and all Na⁺ channels tested (Na_V1.2, Na_V1.5, Na_V1.7 and Na_V1.8). The toxin shifts the voltage-dependence of channel activation to more positive potentials.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

10-500 nM.

ProTx-II inhibits Na_V channels¹. ProTx-II could also modulate T-type Ca²⁺ channels at higher concentrations².

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (1000 X g 5 min).

Up to one week at 4°C or three months at -20°C.

Synthetic peptide

2-5 µM.

Pterinotoxin-1 inhibits rat voltage-gated Na⁺ channels Na_V1.3, Na_V1.7 and Na_V1.8.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

20 mM ammonium acetate, pH =6. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

0.5-1 µM.

Pterinotoxin-2 inhibits voltage-gated Na⁺ Na_V1.3 and Na_V1.7 channels¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Soluble in water. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Tetraodon pardalis (puffer fish).

100 nM - 1 μM.

Tetrodotoxin is a potent and selective blocker of a subclass of Na_V channels¹, and is often used to define subclasses of Na_V channels².

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

TTX citrate is freely soluble in water to over 10 mM. The reconstituted product contains citrate buffer.
To reconstitute 1 mg lyophilized product to 10 mM stock solution – add 313 µl ddH₂O to the vial and tap gently until fully dissolved. To reconstitute 50 µg lyophilized product to 1 mM stock solution – add 157 µl ddH₂O to the vial and tap gently until fully dissolved.
Centrifuge all product vials before handling and reconstitution (10000 x g 5 min).

Up to one week at 4°C or six months at -20°C.

Synthetic peptide

200-500 nM.

VSTX3 inhibits voltage-gated Na⁺ channels Na_V1.3, Na_V1.7 and Na_V1.8¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Soluble in water. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.